Current Issue

Advanced Journal of Pharmacie and Life science Research (AJPLR) volume 7 Issue 4 Oct-Dec 2019


A REVIEW ON THE PLAUSIBLE EFFECTS OF NIMBOLIDE

Nimbolide is one of the chief components in the leaf extract of Azadirachta indica (A.indica). Vibrant evidence from various in vitro and in vivo studies reveal that nimbolide possesses various biological activities and also shows potential chemopreventive activity in animal models. The major mechanisms of action of nimbolide include anti-proliferation, induction of apoptosis, inhibition of metastasis and angiogenesis, and modulation of carcinogen-metabolizing enzymes. Although numerous pharmacodynamic studies have been carried out, nimbolide is still at the infant stage in the drug development pipeline due to the lack of systematic pharmacokinetic studies and long-term toxicological studies. Therefore this review aims at exploring the various effects of Nimbolide in a short manner.
Anandakumar Pandi1, Gizaw Mamo1, Lemma Amsalu1, Vanitha Manickam Kalappan2
[ PDF]