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Oct-Dec 2019 | volume 7 | Issue 4


Nimbolide is one of the chief components in the leaf extract of Azadirachta indica (A.indica). Vibrant evidence from various in vitro and in vivo studies reveal that nimbolide possesses various biological activities and also shows potential chemopreventive activity in animal models. The major mechanisms of action of nimbolide include anti-proliferation, induction of apoptosis, inhibition of metastasis and angiogenesis, and modulation of carcinogen-metabolizing enzymes. Although numerous pharmacodynamic studies have been carried out, nimbolide is still at the infant stage in the drug development pipeline due to the lack of systematic pharmacokinetic studies and long-term toxicological studies. Therefore this review aims at exploring the various effects of Nimbolide in a short manner.
Anandakumar Pandi1, Gizaw Mamo1, Lemma Amsalu1, Vanitha Manickam Kalappan2
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Advanced Journal of Pharmacie and Life science Research (AJPLR) ISSN 2454-3535 is an international peer reviewed quarterly published journal focused on review and research in Pharmaceutical and life science field.The aim of AJPLR is to encourage scientists, academicians and students to publish their experimental and theoretical details. AJPLR provides an advanced knowledge platform for the pharmaceutical and life science.

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